The second half saw David Silva make his home debut, coming on for Isak shortly after the hour, while Casemiro, Fede Valverde and youngster Marvin Park, making his Madrid debut, came on for Zidane's side with 20 minutes left to play.
Qingdao went one player down eight minutes after the break as Yin Yaji collected his second yellow card.
On Thursday, R&F had more ball possession, but it was Shenhua who fielded 11 native players in the starting line-up and created more real chances.
After the restart, Esteghlal were quick to cement their place in the Round of 16 with a third goal, as Karimi supplied a chipped cross from the edge of the penalty area for Cheick Diabate, who guided his header past Al Owais to make it 3-0.
Wuhan ranked fifth with 16 points, only one point behind the fourth-placed Shijiangzhuang Ever Bright and two points behind the third-placed Hebei China fortune, while Chongqing sat sixth with 15 points before the match.
Sergio Busquets, Frenkie de Jong, Philippe Coutinho and new arrival Miralem Pjanic battle it out for three spots in midfield with Francisco Trincao likely to wait his turn on the bench.
Both sides accelerated their rhythm in the second set, but Hebei could hardly break through the tight blocks cemented by Xu Ruoya and Wang Chenyue as Jiangsu had an identical winning scoring for the second set.
"I am shocked and saddened to learn of the death of eight young sons of our great football family who died following a car accident on Saturday. I hasten to extend to you, on behalf of all members of the CAF Executive Committee, the sincerest condolences and I wish a speedy recovery to the injured," he said.
DOHA, Sept. 22 (Xinhua) -- Sharjah scored five goals in the second half for a convincing 6-0 victory over Al Taawoun FC, moving to the second place in Group C of the 2020 AFC Champions League on Monday.
Semedo's sale to Wolverhampton Wanderers means the defense virtually picks itself with Sergi Roberto, Jordi Alba, Gerard Pique and Clement Lenglet continuing together, while Ter Stegen's knee operation means Norberto Neto will make a rare start.
Mexico are currently 11th in the FIFA rankings while Guatemala are 130th. Enditem